Genetic analysis of lymphocyte development and lymphoid system diseases.
B and T lymphocytes are responsible for carrying out antigen specific immune reactions and maintaining immune memory against pathogens. The generation and maintenance of a broad repertoire of antigen specific lymphocytes must be tightly regulated throughout life. Perturbation of the regulatory events either by genetic defects or environmental factors may lead to immune system diseases such as immune deficiency, autoimmune syndromes, or leukemia. This laboratory uses molecular biology and mouse genetics to discover the basic principles guiding B and T lymphocyte development and to investigate the genetic basis of lymphoid diseases.