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Scott Soderling

Associate Professor
Cell Biology
919-452-9231
Research Interest: 
Developmental biology
Neurobiology
Signal transduction
Research Summary: 
Regulation of the cytoskeleton during normal neural development and its linkage to intellectual disability, autism, and schizophrenia.
Research Description: 

My laboratory is interested in two broad questions. 1) How is Rho-family GTPase signaling to the actin cytoskeleton in neurons regulated by multi-protein complexes? 2) How does the organization of these signaling pathways translate to the regulation of normal neuronal function or disorders such as intellectual disability, schizophrenia, or autism?
To answer these questions our laboratory utilizes a combination of mouse genetics, proteomics, cellular imaging, and behavioral analysis.

Publications: 
SH3 domain-based phototrapping in living cells reveals Rho family GAP signaling complexes.
Okada H, Uezu A, Mason FM, Soderblom EJ, Moseley MA, Soderling SH.
Sci Signal. 2011. 4:rs13.

WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory.
Carlson BR, Lloyd KE, Kruszewski A, Kim IH, Rodriguiz RM, Heindel C, Faytell M, Dudek SM, Wetsel WC, Soderling SH.
J Neurosci. 2011. 31:2447-60.

Bi-modal regulation of a formin by srGAP2.
Mason FM, Heimsath EG, Higgs HN, Soderling SH.
J Biol Chem. 2011. 286:6577-86.

Regulation of the postsynaptic cytoskeleton: roles in development, plasticity, and disorders.
Svitkina T, Lin WH, Webb DJ, Yasuda R, Wayman GA, Van Aelst L, Soderling SH.
J Neurosci. 2010. 30:14937-42.

Peptide array X-linking (PAX): a new peptide-protein identification approach.
Okada H, Uezu A, Soderblom EJ, Moseley MA, Gertler FB, Soderling SH.
PLoS One. 2012. 7:e37035.