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Sandeep Dave

Associate Professor
(919)681-1912
Research Interest: 
Genetics
Immunology
Signal transduction
Research Summary: 
Application of high-throughput technologies in conjunction with traditional experimental methods to better understand the biology of cancers.
Research Description: 

Active efforts in the laboratory and clinic include:
Application of high throughput sequencing to identify means of gene regulation in normal and malignant cells.
Integrating genomic technologies with clinical trials to define molecular subgroups of patients who are most likely to respond to therapy.
Generating novel models of cancers based on genetic mutations that occur in human tumors.

Publications: 
Molecular diagnosis of Burkitt's lymphoma.
Dave SS, Fu K, Wright GW, Lam LT, Kluin P, Boerma EJ, Greiner TC, Weisenburger DD, Rosenwald A, Ott G, Müller-Hermelink HK, Gascoyne RD, Delabie J, Rimsza LM, Braziel RM, Grogan TM, Campo E, Jaffe ES, Dave BJ, Sanger W, Bast M, Vose JM, Armitage JO, Connors JM, Smeland EB, Kvaloy S, Holte H, Fisher RI, Miller TP, Montserrat E, Wilson WH, Bahl M, Zhao H, Yang L, Powell J, Simon R, Chan WC, Staudt LM, Lymphoma/Leukemia Molecular Profiling Project.
N Engl J Med. 2006. 354:2431-42.

A loss-of-function RNA interference screen for molecular targets in cancer.
Ngo VN, Davis RE, Lamy L, Yu X, Zhao H, Lenz G, Lam LT, Dave S, Yang L, Powell J, Staudt LM.
Nature. 2006. 441:106-10.

Oncogenic CARD11 mutations in human diffuse large B cell lymphoma.
Lenz G, Davis RE, Ngo VN, Lam L, George TC, Wright GW, Dave SS, Zhao H, Xu W, Rosenwald A, Ott G, Muller-Hermelink HK, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Chan WC, Staudt LM.
Science. 2008. 319:1676-9.

Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells.
Dave SS, Wright G, Tan B, Rosenwald A, Gascoyne RD, Chan WC, Fisher RI, Braziel RM, Rimsza LM, Grogan TM, Miller TP, LeBlanc M, Greiner TC, Weisenburger DD, Lynch JC, Vose J, Armitage JO, Smeland EB, Kvaloy S, Holte H, Delabie J, Connors JM, Lansdorp PM, Ouyang Q, Lister TA, Davies AJ, Norton AJ, Muller-Hermelink HK, Ott G, Campo E, Montserrat E, Wilson WH, Jaffe ES, Simon R, Yang L, Powell J, Zhao H, Goldschmidt N, Chiorazzi M, Staudt LM.
N Engl J Med. 2004. 351:2159-69.

Patterns of microRNA expression characterize stages of human B-cell differentiation.
Zhang J, Jima DD, Jacobs C, Fischer R, Gottwein E, Huang G, Lugar PL, Lagoo AS, Rizzieri DA, Friedman DR, Weinberg JB, Lipsky PE, Dave SS.
Blood. 2009. 113:4586-94.