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Paul Magwene

Associate Professor
Biology
(919) 613-8159
Research Interest: 
Genetics
Microbiology and virology
Signal transduction
Research Summary: 
Understanding how genetic variation affects signal transduction and gene regulatory networks, and how in turn variation in such networks affects cellular phenotypes.
Research Description: 

After completing my graduate studies in Evolutionary Biology at the University of Chicago, I undertook postdoctoral training in Population and Quantitative Genetics (Yale University) and Computational Biology and Bioinformatics (Yale and University of Pennsylvania). My cross-disciplinary training is reflected in my current research program which sits at the interface of evolutionary genetics, computational biology, and systems biology. Projects in my laboratory are aimed at understanding how genetic variation affects signal transduction and gene regulatory networks, and how in turn variation in such networks affects cellular and organismal phenotypes. Our primary experimental system is the budding yeast, Saccharomyces cerevisiae; more recently we have begun to incorporate the fungal pathogen Cryptococcus neoformans into our studies. Recent project have focused on the cellular and genetic basis of fungal biofilms, filamentous growth, and replicative aging.

Publications: 
The 100-genomes strains, an S. cerevisiae resource that illuminates its natural phenotypic and genotypic variation and emergence as an opportunistic pathogen.
Strope PK, Skelly DA, Kozmin SG, Mahadevan G, Stone EA, Magwene PM, Dietrich FS, McCusker JH.
Genome Res. 2015. 25:762-74.

Modeling mutant phenotypes and oscillatory dynamics in the Saccharomyces cerevisiae cAMP-PKA pathway.
Gonzales K, Kayıkçı O, Schaeffer DG, Magwene PM.
BMC Syst Biol. 2013. 7:40.

The genetic architecture of biofilm formation in a clinical isolate of Saccharomyces cerevisiae.
Granek JA, Murray D, Kayrkçi Ö, Magwene PM.
Genetics. 2013. 193:587-600.

Outcrossing, mitotic recombination, and life-history trade-offs shape genome evolution in Saccharomyces cerevisiae.
Magwene PM, Kayıkçı Ö, Granek JA, Reininga JM, Scholl Z, Murray D.
Proc Natl Acad Sci U S A. 2011. 108:1987-92.

Environmental and genetic determinants of colony morphology in yeast.
Granek JA, Magwene PM.
PLoS Genet. 2010. 6:e1000823.