Multidisciplinary approaches for studying metabolism and its contribution to disease, particularly cancer. A list of publications is found at: http://www.ncbi.nlm.nih.gov/pubmed/?term=locasale+j
Our efforts focus on two areas: 1.) Understanding basic biology of metabolic regulation of chromatin state. 2.) Defining the contexts in which targeting metabolism in cancer may be effective.
We study two pathways that interweave into both of these areas: 1.) Central carbon involving glycolysis and the citric acid cycle. 2.) Amino acid metabolism through serine, glycine, and one carbon metabolism.
There is an immediate clinical importance in studying these networks. Agents that target these networks are either 1.) currently being investigated for their merits as cancer drugs with some as far along as Phase III trials, 2.) readily available by prescription and are being considered for repurposing for cancer therapy and prevention, or 3.) currently used as frontline chemotherapies with mixed results but the determinants of their efficacy are not known.