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Gregory Taylor

Associate Professor
Molecular Genetics and Microbiology
9192860411 7740
Research Interest: 
Immunology
Research Summary: 
Mechanisms of innate immunity, particularly those provided by the IRG proteins in mice and humans.
Research Description: 

The Taylor lab is interested in innate immune mechanisms that underpin inflammatory processes and resistance to intracellular bacteria and protozoa. For a number of years, we have focused on a family of proteins known as Immunity-Related GTPases (IRG; also known as p47 GTPases), which have been associated with both Crohn’s Disease and resistance to mycobacterial infections in humans. We were among the first to clone IRG genes in the mouse and to define their biochemical activity, cellular localization, and cellular functions, prominent among which is regulation of autophagy. By generating mice that lack certain IRG genes (Irgm1, Irgm3, and Irgd), we have been able to demonstrate the key, but distinct roles that individual IRG proteins play in suppressing inflammation, and in resistance to pathogens such as Salmonella typhimurium, Listeria monocytogenes, and Toxoplasma gondii. We continue to apply a range of biochemical, cellular, and physiological approaches to pinpoint the functions of these and related proteins, with the ultimate goal of generating new therapies for human inflammatory and infectious disease.

Publications: 
Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy.
Traver MK, Henry SC, Cantillana V, Oliver T, Hunn JP, Howard JC, Beer S, Pfeffer K, Coers J, Taylor GA.
J Biol Chem. 2011. 286:30471-80.

Regulation of macrophage motility by Irgm1.
Henry SC, Traver M, Daniell X, Indaram M, Oliver T, Taylor GA.
J Leukoc Biol. 2010. 87:333-43.

Balance of Irgm protein activities determines IFN-gamma-induced host defense.
Henry SC, Daniell XG, Burroughs AR, Indaram M, Howell DN, Coers J, Starnbach MN, Hunn JP, Howard JC, Feng CG, Sher A, Taylor GA.
J Leukoc Biol. 2009. 85:877-85.

Human IRGM induces autophagy to eliminate intracellular mycobacteria.
Singh SB, Davis AS, Taylor GA, Deretic V.
Science. 2006. 313:1438-41.

p47 GTPases: regulators of immunity to intracellular pathogens.
Taylor GA, Feng CG, Sher A.
Nat Rev Immunol. 2004. 4:100-9.