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Amanda Hargrove

Assistant Professor, Chemistry
(919) 660-1522
Research Interest: 
Genetics
Microbiology and virology
Molecular structure
Research Summary: 
Harnessesing the unique properties of small organic molecules to study the structure, function and therapeutic potential of long noncoding RNAs (lncRNAs).
Research Description: 

The discovery of long noncoding RNAs (lncRNAs) has caused a paradigm shift in molecular biology and speculation as to their role as the master drivers of diseases such as cancer. At the same time very little is known about their structure and function, leading some to call the field a veritable “Wild West.” Small molecules are the perfect tools for such exploration, and the Hargrove lab works at the interface of chemistry and biology, employing methods ranging from RNA-targeted small molecule synthesis and array-based pattern recognition to studies of the molecular and cellular biology of nucleic acids. Collaborations with several departments across campus ensure that these tools are applied to the most important unsolved problems in the fundamental biology and disease-related actions of long noncoding RNAs.

Publications: 
Biochemical Methods To Investigate lncRNA and the Influence of lncRNA:Protein Complexes on Chromatin.
McFadden EJ, Hargrove AE.
Biochemistry. 2016. 55:1615-30.

Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide.
Hargrove AE, Martinez TF, Hare AA, Kurmis AA, Phillips JW, Sud S, Pienta KJ, Dervan PB.
PLoS One. 2015. 10:e0143161.

Characterization and solubilization of pyrrole-imidazole polyamide aggregates.
Hargrove AE, Raskatov JA, Meier JL, Montgomery DC, Dervan PB.
J Med Chem. 2012. 55:5425-32.

Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.
Raskatov JA, Hargrove AE, So AY, Dervan PB.
J Am Chem Soc. 2012. 134:7995-9.

Chemical functionalization of oligodeoxynucleotides with multiple boronic acids for the polyvalent binding of saccharides.
Hargrove AE, Ellington AD, Anslyn EV, Sessler JL.
Bioconjug Chem. 2011. 22:388-96.