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Associate Professor
Molecular Genetics and Microbiology
Our broad research program concerns the study of microbial pathogenesis, innate immunity, and the study of neural-immune communications.
(919) 668-1783
Professor, Departments of Pathology, Immunology and Molecular Genetics & Microbiology
Pathology
Host-pathogen cross talk and mast cell modulation of innate and adaptive immune responses
9196843630
Professor in Medicine, and Associate Professor in MGM
Molecular Genetics and Microbiology
Intracellular signaling pathways that are activated in pathogenic microorganisms and allow survival in the host.
(919) 684-0045
Assistant Professor
Pharmacology and Cancer Biology
Intratumor heterogeneity and its contribution to tumor progression using mouse models.
(919) 681-5479
Dean, School of Medicine & Professor
Clinical Sciences
Mammalian iron homeostasis and human iron diseases
(919) 684-2455
Professor
Pharmacology and Cancer Biology
Mechanisms of signal transduction and intracellular protein sorting in photoreceptor cells; photoreceptor pathobiology; neurobiology of the retina.
(919) 668-5391
Associate Professor
Cell Biology
Cellular and physiologic mechanisms controlling morphogenesis
(919) 681-9268
Assistant Professor
Biology
Nutritional control of C. elegans development
(919) 613-8179
Associate Professor of Biology
Biology
Drosophila as a model system to understand Wnt signal transduction and epidermal cell patterning.
(919) 613-8162
Professor
Biology
Molecular genetic and systems biology approaches to study plant development.
(919) 660-7338
HHMI investigator/James B Duke Professor
Biochemistry
The molecular organization of plasma membranes in differentiated vertebrate cells and to the role of such cellular-level structure in normal physiology and disease.
919-684-3538
Assistant Professor
Biology
Understanding how neural circuits drive behavior
(919)-684-1703
Edwin L. Jones, Jr. and Lucille Finch Jones Cancer Research Professor
Pathology
Neuro-oncology; cancer genomics; cancer immunology; immunotoxins
919-684-6790
Associate Professor
Pharmacology and Cancer Biology
The role of transforming growth factor-beta (TGF-beta) superfamily signaling pathways in cancer biology.
(919) 668-1352
Assistant Professor of Biochemistry
Biochemistry
Cell signaling through protein glycosylation, using chemical, biochemical and cell biological methods.
(919) 684-9906
Assistant Professor
Biology
The evolution of gene networks using a systems biology approach.
(919) 699-8209
Associate Professor
Neurobiology
Molecular mechanisms of synaptic plasticity; presynaptic function; basal ganglia function and pathology
James B. Duke Professor
Cell Biology
The biology of sex determination and how patterning decisions are made during organ development.
919-684-6390
Research Professor
Molecular Genetics and Microbiology
Nutrient sensing and control of cell growth; relevant to immunosuppressive, anticancer, and fungicidal drug action.
(919) 684-2095
James B. Duke Professor
Cell Biology
Molecular and cellular mechanisms by which G protein-coupled receptors control normal and abnormal physiological functions.
919-684-5433
Assistant Professor
Biology
Light signaling and nuclear organization in plants
(919) 684-8442
Associate Professor
Molecular Genetics and Microbiology
Use of genomic tools to enhance understanding of human diseases and disease-related biological questions.
(919)668-4759
Assistant Professor
Molecular Genetics and Microbiology
Fundamental processes underlying infectious disease.
(919)684-7109
Professor
Pharmacology and Cancer Biology
Molecular analysis of Ras signaling in cancer
(919) 684-9890
Associate Professor
Clinical Sciences
Identification of gene regulatory elements across the genome to help us understand how chromatin structure dictates cell function and fate.
919-684-8196
James B. Duke Professor of Molecular Genetics & Microbiology
Molecular Genetics and Microbiology
MicroRNAs and how they influence virus replication.
919-684-3031
Associate Professor, Director DUHS Clinical Molecular Diagnostics Laboratory
Pathology
Development of multigene assays to determine cancer patient-specific prognoses.
(919) 684-2698
Associate Professor
Application of high-throughput technologies in conjunction with traditional experimental methods to better understand the biology of cancers.
(919)681-1912
Assistant Professor of Chemistry and Molecular Genetics and Micriobiology
Multidisciplinary research group that addresses global health problems usiing the interface of chemistry and biology.
(919) 660-1511
Associate Professor
Clinical Sciences
Cancer Biology, including regulation of apoptosis in therapeutic resistance, tumor-immune microenvironment, growth factor receptors, and genomics
919 668 0410
Assistant Professor
Cell Biology
The control of cell division and cell differentiation during embryonic development.
(919) 684-8079
Professor of Computer Science and Biochemistry
Computer Science
Computational methods in biological macromolecular NMR; enzyme design in the non-ribosomal peptide synthetase pathway, protein design, drug design, antibody design.
(919) 660-6583
Arts and Sciences Professor of Biology, HHMI-GBMF Investigator
Biology
Plant-Microbe interactions
(919) 613-8176
Professor of Cell Biology
Cell Biology
Motor proteins, kinesin microtubule motors, Ncd, meiosis, spindle dynamics, mitosis
(919) 684-4311
James B. Duke Professor
Cell Biology
Cytoskeleton and cell motility, especially the bacterial tubulin homolog FtsZ, the key player in bacterial cell division; Extracellular matrix, especially fibronectin.
919 684 6385
Associate Professor
Cell Biology
Role of astrocytes in synaptic connectivity
(919) 684-3605
Associate Professor
Clinical Sciences
Intracellular signaling and protein-organelle trafficking in health and disease
(919)684-8457
Assistant Professor
Pharmacology and Cancer Biology
Tissue repair and genome stability.
919-613-8756
Assistant Professor
Pharmacology and Cancer Biology
Regulation of primary cilia and their role in development and human disease.
(919) 684-3529
Assistant Professor
Neurobiology
Molecular mechanisms of nociception, specifically the mechanisms of sensory ion channels involved in sensing temperature and touch.
(919) 684-1144
Professor
Biochemistry
Gene Function and Regulation, Nucleic Acids Biochemistry, RNA Biochemistry
(919) 684-4034
Associate Professor
Clinical Sciences
Mechanisms of protein synthesis regulation and ways to exploit abnormal signal transduction to translation machinery for cancer treatment.
919-668-6205
Associate Professor
Biology
Control of cell division in budding yeast.
(919) 613-8205
Professor
Pathology
Mechanisms for generating normal and pathologic immune responses, primarily in the context of inflammatory bowel disease.
(919) 684-4771
Assistant Professor
Immunology
Signaling pathways that govern how dendritic cells interact with microbial commensals in the intestine.
(919) 660-9003
Assistant Professor, Chemistry
Harnessesing the unique properties of small organic molecules to study the structure, function and therapeutic potential of long noncoding RNAs (lncRNAs).
(919) 660-1522
Director, Duke Human Vaccine Institute; Leader, Laboratory of B cell Biology
Clinical Sciences
Overcoming host factors that prevent induction of B cells producing broadly protective antibodies for HIV-1, influenza vaccine development.
(919) 684-5279
Associate Professor
Pharmacology and Cancer Biology
Smooth and striated muscle plasticity in response to physiological stress, drug discovery in obesity, and drug discovery in infectious diseases.
919-613-8606
Professor/M.D. Ph.D.
Immunology
T lymphocyte biology, lymphocyte apoptosis, autophagy, human viral infection, T lymphocyte functional exhaustion
(919)613-7870
Assistant Professor
Molecular Genetics and Microbiology
Understanding the interaction between respiratory RNA viruses and their hosts.
(919) 684-1351
James B. Duke Professor and Chair
Molecular Genetics and Microbiology
How cells sense and respond to their environments; molecular mechanisms of sex determination and the impact of sexual reproduction on evolution and microbial virulence
(919) 684-2824
Associate Professor in Orthopaedic Surgery and Cell Biology
Cellular and molecular mechanisms that regulate skeletal development, disease, and repair or regeneration.
(919) 613-9761
Assistant Professor
Pharmacology and Cancer Biology
Mitochondrial function and small metabolite regulation of nutrient metabolism by post-translational modifications.
(919) 479-2315
Professor and Chair
Cell Biology
Organogenesis and stem cells
919-684-8085
Molecular Genetics and Microbiology
Intracellular innate immunity to hepatitis C virus and other RNA viruses
(919) 684-1921
Assistant Professor
Neurobiology
Genetic and epigenetic basis of neurodevelopmental disorders
919-681-2789
Professor
Molecular Genetics and Microbiology
Regulation of eukaryotic genome stability using budding yeast as a model genetic system.
(919) 681-7273
Assistant Professor of Orthopaedic Surgery and Cell Biology
The role and molecular regulation of cellular metabolism during musculoskeletal development and disease.
(919) 668.5664
Assistant Professor
Neurobiology
Molecular mechanisms of neural circuit wiring in developing retina.
(919) 613-4769
James B. Duke Professor
Molecular Genetics and Microbiology
Coordination of gene expression on the post-transcriptional level by RNA-binding proteins and small noncoding RNAs.
Professor
Biology
Molecular mechanisms for force production in morphogenesis using biophysical, genetic, and pharmacological approaches, coupled with 4D imaging.
(919)613-8157
Associate Dean, Graduate School and Associate Professor
Cell Biology
The mechanisms of organ and tissue formation during development
Assistant Professor
Molecular Genetics and Microbiology
Identification and characterization of human genetic variation affecting infection and inflammation.
Clinical Sciences
Developement of new therapy for genetic diseases
(919)681-9919
Provost of Duke University and James B Duke Professor
Pharmacology and Cancer Biology
The basic biology of programmed cell death (apoptosis) and cell cycle progression as well as the potential for modulating these signaling pathways to enhance cancer therapy.
919 668 4729
Professor and Chair
Immunology
Molecular mechanisms that regulate V(D)J recombination at T cell receptor loci during mouse T lymphocyte development.
919-684-4985
Professor of Medicine, Professor of Pathology, Associate Professor of Surgery
Pathology
Pathogenesis of arthritis and development of novel biomarker tools to aid in the diagnosis, prognosis, monitoring, and effective intervention of the disease in humans and animal model systems.
919-681-6652
Professor of Medicine; Assistant Professor Cell Biology
Clinical Sciences
Molecular mechanisms whereby skeletal muscle adaptation mediate the health benefits of exercise training.
(919) 681-6733
Associate Professor
Biochemistry
Biochemical and genetic analysis of secretory outer membrane vesicles produced by pathogenic bacteria.
(919) 684-2545
Professor
Pharmacology and Cancer Biology
Reciprocal interactions of hormones, monoamine neuron function, and psychiatric diseases, especially addiction and depression, in animal models.
919-684-8828
George W. Brumley Associate Professor
Cell Biology
Adult neurogenesis and how the production of new neurons in the brain is sustained and regulated.
(919) 684-4612
Associate Professor
Clinical Sciences
Research Summary (one sentence) This laboratory focuses on targeting the neurokinin-1 receptor in glioblastomas and understanding the molecular basis of postoperative delirium.
(919)681-4775
Associate Professor
Cell Biology
How the three-dimensional structures of cell and tissues are generated and maintained.
(919) 684-4550
Assistant Professor
Biochemistry
Structural and functional studies of ion channels and transporters
919-684-1005
James B. Duke Professor of Medicine
Biochemistry
Molecular properties and regulatory mechanisms that control the function of plasma membrane receptors for hormones and drugs.
(919) 684-2974
James B. Duke Professor
Pharmacology and Cancer Biology
Control of cell polarity and its relation to the cell cycle in yeast.
(919) 613-8627
Professor of Dermatology, Cancer Biology and Pharmacology
Clinical Sciences
Novel roles of caspases in regulating stemness, epigenetic cellular plasticity, and tumor response to radiation therapy and chemotherapy.
(919) 613-8754
Assistant Professor of Immunology
Immunology
microRNA regulation during the T cell development and differentiation
9196684070
Assistant Professor; Attending Physician
Clinical Sciences
Sensory transduction, transmission, and the role of calcium signaling mechanisms; physiology and maladaptation in chronic pathological pain.
919 684 0058
Associate Professor Pediatrics,
Pharmacology and Cancer Biology
Mechanisms of sarcomagenesis; senescence; modeling cancer from primary human cells.
(919) 681-3508
Assistant Professor
Clinical Sciences
Autophagy lysosomal pathway in ocular physiology and pathophysiology.
(919) 681 4085
Assistant Professor
Pharmacology and Cancer Biology
Multidisciplinary approaches for studying metabolism and its contribution to disease, particularly cancer. A list of publications is found at: http://www.ncbi.nlm.nih.gov/pubmed/?term=locasale+j
(919) 684-9309
Associate Professor
Molecular Genetics and Microbiology
Mechanisms of viral oncogenesis and host response to oncogenic virus infection
919-668-3091
Associate Professor
Pharmacology and Cancer Biology
Mechanisms by which the molecular architecture of the chromosome regulates fundamental biological processes such as replication and transcription.
919.681.6077
Associate Professor
Biology
Understanding how genetic variation affects signal transduction and gene regulatory networks, and how in turn variation in such networks affects cellular phenotypes.
(919) 613-8159
Assistant Professor of Ophthamology
Clinical Sciences
Molecular mechanisms and signaling pathways underlying retinal diseases including age-related macular degeneration and diabetic retinopathy.
(919) 684 0820
Professor
Molecular Genetics and Microbiology
The genetics of cardiovascular disease using both the human and the mouse as a model system.
919 684-1945
Associate Professor
Clinical Sciences
The etiology of human breast and ovarian cancer.
9196846133
Professor
Molecular Genetics and Microbiology
Molecular mechanisms of smell and other chemical senses
(919) 684-2777
Arthur S Pearse Professor of Biology
Biology
Systems level approaches to study control and execution of morphogenetic movements in sea urchin embryos.
(919) 613-8188
Associate Professor
Molecular Genetics and Microbiology
Chronological life span and quantitative genetics in yeast.
Glaxo-Wellcome Professor of MCB and Chair
Pharmacology and Cancer Biology
Identification of druggable targets within estrogen- and androgen-regulated signal transduction pathways that can be exploited in the development of novel breast and prostate cancer therapeutics.
(919) 684-6035
Professor of Cell Biology
Cell Biology
Membrane structure; protein-lipid interactions; roles of lipids on membrane channel activities
919-684-8950
Assistant Professor of Orthopaedic Surgery & Pathology
Development of strategies to prevent osteoarthritis and promote tissue repair and regeneration following joint injury. Understanding the mechanotransduction pathways that modulate cartilage and meniscus homeostasis and how these signaling pathways are altered with aging and pathology to reveal potential targets to prevent joint tissue degeneration and osteoarthritis.
(919) 684-6882
Assistant Professor
Biochemistry
We study mRNA modifications and their role in nervous system function.
(919) 684-9562
George Barth Geller Professor
Neurobiology
How experience affects brain and behavior.
(919)684-5025
Associate Professor
Pharmacology and Cancer Biology
Mechanisms of metabolic regulation and metabolic disease; impact of diet and exercise on skeletal muscle physiology; interplay between mitochondrial bioenergetics and insulin action.
(919) 479-2328
Associate Professor
Clinical Sciences
Gynecologic cancer etiology and biology, cancer stem cells, the establishment and maintenance of DNA methylation in humans and how epigenetic deregulation is associated with disease.
(919) 681-3423
Associate Dean for Research Training and Professor
Cell Biology
The spatiotemporal regulation of mRNA translation and how such regulation defines the subcellular architecture of protein synthesis.
(919) 684-8948
Professor
Biochemistry
Physical chemistry of biological macromolecules: kinetics, thermodynamics, spectroscopy and structure.
919 684-4363
James and Alice Chen Professor of Radiology, Professor in Pharmacology and Cancer Biology, Professor in Pathology
Clinical Sciences
Translational issues related to early cancer detection and mechanisms of metastasis.
919-684-7311
Professor and Vice Chair, Pharmacology & Cancer Biology
Pharmacology and Cancer Biology
Regulation of cellular signaling networks by tyrosine kinases in development and cancer.
919-681-8086
Professor
Molecular Genetics and Microbiology
The genetic regulation of genome stability and the mechanism of mitotic recombination.
919 684-4986
Associate Professor
Molecular Genetics and Microbiology
Viral suppression of immune responses to infection, and the development of live-virus vaccines to improve protection against viral infections.
(919) 684-2480
Professor
Cell Biology
Genetic approaches to organ regeneration in zebrafish
(919) 681-8457
Associate Professor
Molecular Genetics and Microbiology
Microbial regulation of intestinal physiology; adipose tissue development and metabolic disease.
Assistant Professor
Immunology
Understanding the differentiation, function, and plasticity of CD4 T cells in the context of various allergic, inflammatory, and malignant disorders.
919-684-4829
Professor
Biochemistry
Structural Bioinformatics: concepts and computer tools to visualize, analyze, and correct protein and RNA structures.
919-684-6010
James B. Duke Professor
Biochemistry
3D structural bioinformatics of protein and RNA: structures, interactions, motions, & design; techniques for improving model accuracy.
919-684-6010
Edward S. Orgain Professor of Cardiology
Clinical Sciences
Molecular mechanisms of cardiac hypertrophy and heart failure
919-668-2520
Assistant Professor
Biology
Systems biology of archaea: understanding regulatory network responses to environmental extremes
919-613-4464
Professor, Human Vaccine Institute
Pathology
Immune senescence associated with aging, and the host response to infectious agents and/or vaccination.
(919) 684-4386
Associate Professor of Biomedical Engineering
Using systems biology to study spatiotemporal controls of multicellular systems, and how their subversion lead to diseases.
(919) 681-9184
Associate Professor in Medicine, Assistant Professor in Cell Biology
Dynamics and functional roles of post-translational modifications of seven-transmembrane G protein-coupled receptors and β-arrestins.
(919) 681-5061
Associate Professor
Biology
Cell invasion through extracellular matrix, stem cell-niche interactions, cellular pausing
919-684-8658
Assistant Research Professor
Biology
Functions of spastin and other microtubule severing proteins in the nervous system; Drosophila models of human disease
(919) 684-8658
Assistant Professor
Immunology
Innate immunity impacts on adaptive immunity during development of diseases, such as cancer, infections, and autoimmune diseases.
(919)613-6977
Assistant Professor
Molecular Genetics and Microbiology
Genetic mechanisms of stem cells and neural development
(919) 668-7909
Associate Professor
Cell Biology
Regulation of the cytoskeleton during normal neural development and its linkage to intellectual disability, autism, and schizophrenia.
919-452-9231
University Distinguished Service Professor, Director of Duke NMR Spectroscopy Center
Biochemistry
Studies of molecular structures, assembly mechanisms and function of biological macromolecular machines with physical biochemistry methods.
(919)684-4327
Professor
Pathology
Development of vaccine adjuvants and vaccination methods to deliver vaccines by mucosal routes without the use of needles.
919-684-8823
Professor and Director Duke Translational Research Institute
Inventing and developing nucleic acid based therapies for the treatment of cardiovascular diseases and cancer.
919-684-6375
Associate Professor
Molecular Genetics and Microbiology
Epigenetic regulation of the human genome, with a specific emphasis on centromeres and chromosome structure and behavior.
(919) 684-9038
Professor of Biology
Biology
Molecular genetics of growth hormone-mediated plant development.
(919) 613-8166
Assistant Professor
Cell Biology
Understanding the cellular and molecular basis of cell plasticity in organ regeneration and tumorigenesis.
(919) 684-0624
Associate Professor
Molecular Genetics and Microbiology
Mechanisms of innate immunity, particularly those provided by the IRG proteins in mice and humans.
9192860411 7740
Alter E. Geller Professor for Research in Immunology
Immunology
B lymphocyte function and the structure of cell surface molecules that regulate B cell function, activation and signal transduction.
(919) 684-3681
Professor
Pharmacology and Cancer Biology
Regulation of stress-responsive gene expression and roles of metals in growth, development, signaling and microbial pathogenesis
919-684-5776
Assistant Professor
Molecular Genetics and Microbiology
Tuberculosis: Mycobacterial pathogenesis and host susceptibility.
(919) 684-9152
Vice Dean of Basic Sciences and Associate Professor
Molecular Genetics and Microbiology
Biochemical, functional genomic and cell biological approaches to understand how intracellular bacterial pathogens manipulate their host cells.
919-668-3831
Assistant Professor
Biology
The developmental processes that establish the basic organizational and functional principles of the neuronal circuits in the brain.
(919)684-1150
Assistant Professor of Medicine and Immunology
How the cholesterol biosynthesis pathway regulates innate and adaptive immune responses and its implication in autoimmune, inflammatory diseases.
(919) 684-5586
Associate Professor
Cell Biology
Neural circuits of the mouse orofacial sensory-motor system
(919)684-3682
Donald and Elizabeth Cooke Professor of Experimental Oncology
Pharmacology and Cancer Biology
Molecular nature and signaling mechanism of tumor microenvironment associated with tumor progression and metastasis.
919-681-4861
Associate Professor of Neurobiology
Neurobiology
Mechanisms and consequences of stimulus-regulated transcription in the central nervous system.
(919)681-1909
Assistant Professor
Pharmacology and Cancer Biology
New functional genomics technologies and their applications in basic and translational cancer biology
(919) 613-8634
Professor
Biology
Evolutionary genetics of gene expression
(919) 684-6696
Assistant Professor
Molecular Genetics and Microbiology
Molecular mechanisms of neural circuit formation and regeneration.
Professor of Pathology
Pathology
Cancer genetics and therapy
(919)-668-7850
Assistant Professor
Biochemistry
The molecular basis of ion and lipid transport across cell membranes and their impacts on health and disease.
(919) 684-1406
Professor of Medicine
Clinical Sciences
Cancer immunology and immune regulation
(919) 668-0932
Assistant Professor
Cell Biology
Epigenetic regulation and nuclear organization in mammalian development and disease.
(919) 668-0460
Assistant professor
Biochemistry
Radical and metallo-enzymology.
(919) 684-8848
Associate Professor
Immunology
Adaptor proteins in immunoreceptor-mediated signaling, cellular activation, and development of autoimmunity
(919)613-7803
Associate Professor of Pediatrics
Clinical Sciences
Signal transduction in the immune system and control of immune cell development and function.
(919) 681-9450
Associate Professor
Biochemistry
NMR methodology and its application to understanding the molecular recognition of essential protein complexes in crucial biological processes.
919-493-0342
Professor
Immunology
Genetic analysis of lymphocyte development and lymphoid system diseases.
(919)613-7824